Reprint of: Cytogenetic and Genome learn 2004, Vol. 104, No. 1-4 The position of chromosome aberrations in evolution and human overall healthiness is easily famous. This quantity brings jointly papers summarizing our present knowlege of the constitution of interphase nuclei, chromosome constitution, mechanisms of aberration formation and the sensible software of this data in radiobiology, biomonitoring of human populations and melanoma study. Molecular cytogenetic options similar to fluorescence in situ hybridization utilizing entire chromosome and sector particular portray DNA probes were effectively used to spot and quantify chromosome aberrations, that is mirrored in different papers of this quantity. The mechanisms of chromosome aberration formation by way of sorts of ionizing radiation are thought of intimately. in addition, the $64000 function of telomeres in keeping chromosome integrity and their involvement in genomic instability are mentioned. a last part is devoted to the medical relevance of chromosome aberrations in human hereditary illnesses, e.g. Fanconi anemia or ataxia telangiectasia, and in lots of human cancers characterised by way of particular translocations or deletions. The learn of chromosome aberrations is of significant relevance in scientific genetics and oncology for prognosis and disorder prevention. therefore this book is suggested examining for cytogeneticists, radiobiologists, oncologists, and post-graduate scholars of genetics and medication.
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